Giddings Group

Research Interest:

Dr. Lesley-Ann Giddings is a natural products chemist interested in exploiting and characterizing secondary metabolic biosynthetic pathways to identify new bioactive agents and better understand how Nature crafts novel pharmacophores. Her research approaches these problems by studying microbes (including extremophiles obtained from various EPA Superfund sites in Vermont) and using stressful growth conditions to induce cryptic gene clusters involved in secondary metabolism. The lab also uses basic biochemical techniques to characterize enzymes involved in secondary metabolic pathways found in microbes. 

Techniques used:

  • LC/MS
  • HPLC
  • NMR
  • PCR
  • Bio-assays
  • DNA sequencing
  • Heterologous gene expression

Lab Group:

  • Miller Judge ’16.5
  • Jeremy Carter ’17
  • Lauren McLean ’17
  • Kate Johnson ’18